INCLUSION BODIES IN BIOTECHNOLOGY

Authors

  • Romana Köszagová
  • Jozef Nahálka

Keywords:

inclusion bodies, protein aggregation, biotechnology, antimicrobial peptides, biomedicine

Abstract

Protein aggregation is commonly observed phenomenon occurring during production of recombinant proteins in genetically engineered organisms over-expressing foreign genes. Aggregation of such recombinant proteins often leads to the formation of insoluble protein clusters named inclusion bodies (IBs). Although usually considered as waste by-products of protein production, over the last decade, this general misconception has been questioned by various studies. Gradual understanding of the structural, molecular and physiological features has revealed promising potential of these so far undesirable cellular products. In the present review we summarize basic characteristics of IBs, their use in antimicrobial peptides production and in various biotechnological fields, including tissue engineering, drug delivery and biocatalysis.

Downloads

Download data is not yet available.

Downloads

Published

2021-03-11

How to Cite

Romana Köszagová, & Jozef Nahálka. (2021). INCLUSION BODIES IN BIOTECHNOLOGY. Journal of Microbiology, Biotechnology and Food Sciences, 9(6), 1191–1196. Retrieved from https://office2.jmbfs.org/index.php/JMBFS/article/view/4515

Issue

Section

Biotechnology