INHIBITORY EFFECTS OF STERCULIA LYCHNOPHORA HANCE ETHANOL EXTRACTS ON BIOFILM FORMATION AND VIRULENCE FACTORS OF PSEUDOMONAS AERUGINOSA

Ly Ta Ngoc; Hsin-Yi Hung; Quyen Nguyen Tu

doi:10.55251/jmbfs.10483

INHIBITORY EFFECTS OF STERCULIA LYCHNOPHORA HANCE ETHANOL EXTRACTS ON BIOFILM FORMATION AND VIRULENCE FACTORS OF PSEUDOMONAS AERUGINOSA

Authors

Ly Ta Ngoc Da Nang University of Technology and Science https://orcid.org/0000-0002-6917-0521
Hsin-Yi Hung School of Pharmacy, College of Medicine, National Cheng University https://orcid.org/0000-0001-7666-2420
N.T.Quyen Biotechnology department, University of Science and Technology, The University of Danang

DOI:

https://doi.org/10.55251/jmbfs.10483

Keywords:

anthranilate-CoA ligase, pyocyanin production, Pseudomonas aeruginosa, Sterculia lychnophora, biofilm formation

Abstract

This study aimed to explore the inhibitory effects of dried fruit ethanol extracts of Sterculia lychnophora Hance (SLHe), a traditional medicinal plant known as Pangdahai, on biofilm formation and virulence factors of Pseudomonas aeruginosa. Screening of bioactive compounds extracted from Sterculia lychnophora revealed a strong binding affinity to anthranilate-CoA ligase (PqsA), which regulates genes involved in pyocyanin production and biofilm formation. The experimental investigation confirmed the inhibitory effects of SLHe on biofilm formation and its ability to disrupt existing biofilms. Additionally, SLHe exhibited reductions in pyocyanin production and protease activity of Pseudomonas aeruginosa. These findings indicate the therapeutic potential of SLHe as a natural alternative for treating bacterial infections, particularly those associated with bacterial biofilm formations.

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Published

2024-03-11

How to Cite

Ta Ngoc, L., Hung, H.-Y., & Nguyen Tu, Q. (2024). INHIBITORY EFFECTS OF STERCULIA LYCHNOPHORA HANCE ETHANOL EXTRACTS ON BIOFILM FORMATION AND VIRULENCE FACTORS OF PSEUDOMONAS AERUGINOSA. Journal of Microbiology, Biotechnology and Food Sciences, e10483. https://doi.org/10.55251/jmbfs.10483

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Issue

Articles in press

Section

Biotechnology

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