ASSOCIATION ANALYSIS OF IGF-1 AND GH GENE SNPs WITH GROWTH AND DEVELOPMENT PERFORMANCE IN SHEEP

Abstract

IGF-1 and GH genes have been proven to be important genes that affect animal growth and development. The purpose of this experiment was to analyse the effect of single nucleotide polymorphism (SNP) of sheep IGF-1 and GH genes on their growth and development performance. The results showed that a SNP site T5299C was detected in the IGF-1 gene, while two SNP sites C408G and T364C were detected in the GH gene. At the T5299C site, the CC genotype in the Charolais ewes, rams, and ram lambs, as well as the TT genotype in the Charolais ewe lambs and the CT genotype in the Australian White rams were dominant genotypes. At the C408G site, the CG genotype in the Charolais ewes and ram lambs, CC genotype in the Charolais rams and Australian White rams, and GG genotype in the Charolais ewe lambs were dominant genotypes. At the T364C site, the CT genotype in the Charolais ewes, ram lambs, and Australian White rams, CC genotype in the Charolais ewe lambs, and TT genotype in the Charolais rams were dominant genotypes. And we found the dominant haplotype combinations of each breed of sheep through the haplotype combinations of different loci. This provides a certain reference for future research on the influence of IGF-1 and GH genes on the growth and development performance of sheep.