BIOACTIVITIES OF DIVERSE ENDOPHYTES ISOLATED FROM THE STEM BARK OF MORUS ALBA L.

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Abstract

Endophytes provide a plethora of potential substances that are used in modern medicine. There is an emergence of interest to discover potential compounds from endophytes due to their abundant availability from renewable sources, and low cost relative to chemically synthesized compounds. Studies have shown that Morus alba plant has potential antioxidant and antibacterial activities. Hence, in the present study we deals with the bioprospecting of endophytes of Morus alba. Stem bark of M. alba was collected from different regions of Gujarat. Total 13 bacteria and 14 fungal endophytes were isolated from the collected samples. Among 27 endophytic isolates, the extract of four isolates showed significant antibacterial activity with a diameter zone ranged from 8.0±0.0 to 22.33±1.262 mm with considerable minimum inhibitory concentration (MIC) values. These four extracts also showed significant inhibition of reactive oxygen species in 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Triterpenoids, flavonoids, and phenols were present in these extracts which might be responsible for these bioactivities. Results of this study concluded that these endophytes isolated from the stem bark of Morus alba L. have an important bioactivities in vitro. These extracts may prove good candidate for the antibacterial and antioxidant agents and can be exploited in pharmaceuticals after further development.