CHEMICAL COMPOSITION ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTIACETYLCHOLINESTERASE AND CYTOTOXICITY OF MURRAYA KOENIGII (L.) SPRENG FRUIT OIL

Gogul Madhusudhanan Ramnath; Shathya Jayaraman; Ramaraj Thirugnanasampandan; Bhuvaneswari Gunasekaran; Akila Gopalakrishnan

doi:10.55251/jmbfs.6135

CHEMICAL COMPOSITION ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTIACETYLCHOLINESTERASE AND CYTOTOXICITY OF MURRAYA KOENIGII (L.) SPRENG FRUIT OIL

Authors

Gogul Madhusudhanan Ramnath Kongundu Arts and Science College https://orcid.org/0000-0001-6235-8735
Shathya Jayaraman
Ramaraj Thirugnanasampandan
Bhuvaneswari Gunasekaran
Akila Gopalakrishnan

DOI:

https://doi.org/10.55251/jmbfs.6135

Keywords:

Murraya koenigii, Essential oil, β-phellandrene, Cytotoxicity, Acetylcholinesterase

Abstract

Plant derived essential oils are easily available source for healthcare purpose and it creates increased attention due to undesirable effects of chemically synthesized drugs. Murraya koenigii (L.) Spreng. raw fruit oil was extracted, and its chemical constituents was analyzed. Antioxidant and acetylcholinesterase inhibitory effect was tested under in vitro. MTT assay for evaluating cytotoxic effect on HeLa cells was done. β-phellandrene was identified as major compound in the extracted fruit oil. Scavenging of DPPH radical, inhibition of lipid peroxidation and protection of deoxyribose were found to be excellent. A dose dependent antiacetylcholinesterase activity of oil was observed with IC₅₀value as 448.12±0.02µg/mL. A significant growth inhibitory effect of oil on cervical cancer cells (HeLa) was measured with an IC₅₀ value of 194.1±0.03µg/mL. Overall, the essential oil extracted from raw fruit of Murraya koenigii (L.) Spreng exhibited several biological properties, and it could be considered for plant-based medicine preparations.

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Published

2023-08-02

How to Cite

Ramnath, G. M., Jayaraman, S., Thirugnanasampandan, R., Gunasekaran, B., & Gopalakrishnan, A. (2023). CHEMICAL COMPOSITION ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTIACETYLCHOLINESTERASE AND CYTOTOXICITY OF MURRAYA KOENIGII (L.) SPRENG FRUIT OIL. Journal of Microbiology, Biotechnology and Food Sciences, 13(3), e6135. https://doi.org/10.55251/jmbfs.6135

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Issue

Vol. 13 No. 3 (2023): December - January

Section

Biotechnology

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