THE CYTOTOXIC EFFECT OF ESSENTIAL OILS CITRUS AURANTIUM PEELS ON HUMAN COLORECTAL CARCINOMA CELL LINE (LIM1863)

Authors

  • Fadi Odeh*
  • Abdulkader Rahmo
  • A. Samir Alnori
  • M. Eyad Chaty

Keywords:

Citrus aurantium, Peels, Essential oils, cytotoxicity, Lim1863

Abstract

Citrus essential oils (EOs) contain different terpens that have been shown to possess antitumor effects. We determined the cytotoxic effect of essential oils of Citrus aurantium L. subspamara peels on a colorectal cancer cell line (Lim1863). Three samples were harvested from three locations in Syria. EOs were extracted by hydrodistilation and analyzed by GC-MS. EOs content of Limonene was96-97.7 % while α-pinene and β-myrcenewere0.35-1% and 0.9-1.4% respectively. Various concentrations of EOs (0.25-48 µl/ml) were added to cultured cells and incubated for 72 h. Cell viability was evaluated using the MTT-based cytotoxicity assay. The obtained IC50 value range of C. aurantium Eos was 2.18-2.44 µl/ml. In conclosion, C. aurantium peels Eos obviously reduced the cell viability and it might have cytotoxic effect against colorectal cancer cell line.

Downloads

Download data is not yet available.

Downloads

Published

2012-06-01

How to Cite

Odeh*, F., Rahmo, A., Samir Alnori, A., & Eyad Chaty, M. (2012). THE CYTOTOXIC EFFECT OF ESSENTIAL OILS CITRUS AURANTIUM PEELS ON HUMAN COLORECTAL CARCINOMA CELL LINE (LIM1863). Journal of Microbiology, Biotechnology and Food Sciences, 1(6), 1476–1487. Retrieved from https://office2.jmbfs.org/index.php/JMBFS/article/view/7223

Issue

Vol. 1 No. 6 (2012): June - July

Section

Biotechnology

License

Copyright (c) 2012 Fadi Odeh*, Abdulkader Rahmo, A. Samir Alnori, M. Eyad Chaty

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All papers published in the Journal of Microbiology, Biotechnology and Food Sciences  are published under a CC-BY licence (CC-BY 4.0). Published materials can be shared (copy and redistribute the material in any medium or format) and adapted (remix, transform, and build upon the material for any purpose, even commercially) with specifying the author(s).