EXPLORATION OF ANTIBACTERIAL AND ANTIPROLIFERATIVE SECONDARY METABOLITES FROM MARINE BACILLUS
DOI:
https://doi.org/10.15414/jmbfs.2019/20.9.3.628-633Keywords:
Antibacterial, antiproliferative, A-549 cell line, Bacillus flexus AVSC4, GC-MS analysis, HT-29 cell lineAbstract
Antiproliferative secondary metabolites producing bacterial strain AVSC4 isolated from marine sediments was identified as Bacillus flexus based on 16S rRNA gene sequence analysis. Under the strategy of liquid- liquid extraction, the crude extract was obtained showed significant antibacterial activity against different clinical pathogens. 0.5% methionine and 0.4% NaCl act as inducers for maximizing the growth and antibacterial activity of strain at pH 7 and 40°C. Heptadecanoic acid and methyl hexadecanoic acid were identified as major and dominant secondary metabolites by GC-MS analysis and also showed significant antiproliferative activity against HT-29 (Human colorectal adenocarcinoma) and A-549 (Lung Cancer) with IC50 value 93.4 µg/ml and 50.04 µg/ml.Downloads
Download data is not yet available.
Downloads
Published
2019-12-01
How to Cite
S. Syed, C., Sairam, M., & V. Audipudi, A. (2019). EXPLORATION OF ANTIBACTERIAL AND ANTIPROLIFERATIVE SECONDARY METABOLITES FROM MARINE BACILLUS. Journal of Microbiology, Biotechnology and Food Sciences, 9(3), 628–633. https://doi.org/10.15414/jmbfs.2019/20.9.3.628-633
Issue
Section
Microbiology
License
Copyright (c) 2019 Chandini S. Syed, Mantri Sairam, Amrutha V. Audipudi
This work is licensed under a Creative Commons Attribution 4.0 International License.
All papers published in the Journal of Microbiology, Biotechnology and Food Sciences are published under a CC-BY licence (CC-BY 4.0). Published materials can be shared (copy and redistribute the material in any medium or format) and adapted (remix, transform, and build upon the material for any purpose, even commercially) with specifying the author(s).