INVESTIGATION OF LIPASE INHIBITORY ACTIVITY OF NOVEL PROBIOTICS ISOLATED FROM IRANIAN DAIRY PRODUCTS
Keywords:Lipase, Inhibitory Activity, Lactic Acid Bacteria, HT-29 Cell Line, Probiotics
The primary cause of metabolic syndrome is obesity, a state in which the body accumulates stockpiles of fat. Lessening of assimilation of dietary fats via suppression of lipase enzyme of the pancreas may incite weight loss. In this work, 21 isolates of lactic acid bacteria (LAB) were monitored for potential novel probiotic traits by means of in vitro methods, comprising of bile salt and acid tolerance, adhesion and lipase inhibitory activity. The findings illustrated that L. fermentum sp D9, L. fermentum sp S14 and L. fermentum sp S8, L. paracasei S11 and L. brevis S15 demonstrated prominent potential probiotic features as well as lipase inhibitory activity in vitro. The traits of opted isolates were as good as to those of L. rhamnosus PTCC 1637, a similar strain to L. rhamnosus GG, which possessed an antidiabetic aptitude. These findings offered that the abovementioned isolates could be administrated as potent anti-obesity probiotics. It should be noted that, more investigations are necessary to evaluate the inhibitory activity of lipase from these strains.
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Copyright (c) 2022 Milad Mohkam, Nazanin Afifi, Aida Roshan Zamir, Reza Heidari, Mohammad Reza Zamani, Navid Nezafat, Younes Ghasemi
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