THE PROTECTIVE AND ANTI-INFLAMMATORY EFFICIENCY OF LYOPHILIZED BLUEBERRY AND STRAWBERRY POLYPHENOLS ON EXPERIMENTALLY INDUCED GASTRIC ULCER IN RATS

Abstract

This study examined the gastro protective effects of lyophilized blueberry and strawberry polyphenols against gastric ulcer induced by indomethacin in rats. The administration of indomethacin significantly increased the ulcer index associated with increased antioxidant, inflammatory, and gastrointestinal examination parameters and decreased SOD and GSH, while the rats treated with both blueberry and strawberry in combination had the lowest ulcer index and the maximum value for ulcer preventive index. Treatment with blueberry and/or strawberry efficiently reduced gastric injury, oxidative stress and proinflammatory cytokines and demonstrated a hopeful role against gastric ulcer.