LIVER, ONE OF THE TARGET ORGAN OF PESTICIDES

Abstract

In our previous works we observed the morphological changes in the rabbit’s liver for the period of 3, 10, 20 and 30 days after bendiorarb exposure. The most frequent change was the inflammatory process which reached the highest intensity on day three of administration of bendiocarb. In the present study we observed the ultrastructural changes in the rabbit´s liver after 10-day of bendiocarb exposure, at a dose 5 mg/kg of body weight.
On the tenth day of bendiorarb exposure we did not observed prominent changes in the rabbit liver. The size and shape of hepatocytes were not markedly changed. Their nuclei were centrally located, euchromatic. Intercellular contacts between adjacent cells showed no visible changes. Hepatocytes were located close to each other without extended intercellular spaces. The most numerous organelles in the hepatocytes were mitochondria. They were round or ovoid-shaped with visible cristae. Rough endoplasmic reticulum (RER) was closely associated with the mitochondria without visible dilatation. In some hepatocytes amount of glycogen was reduced. In these cells we observed dilatation of peripheral cisternae of RER was observed.
Liver acts as a barrier or filter between the digestive system and the rest of the body and has essential role in metabolism of many chemicals and toxic substances entering the organism through the gastrointestinal system. Our study demonstrates that bendiocarb on day 10 caused less prominent ultrastructural changes in the rabbit´s liver. Inflammation, accumulation of Kupffer cells and necrotizing hepatocytes were frequently observed by light microscopy. The electron microscopy revealed less pronounced changes in ultrastructure of the hepatocytes.