MICROWAVE AIDED SYNTHESIS OF ZINC OXIDE NANOCERAMICS: A POTENT BIOACTIVE AGENTS WITH THERAPEUTIC CHARACTERS

Abstract

Nanoparticles have been inexhaustibly utilized in Nanochemistry cohere with Bio-Technology to upgrade the immobilization and movement of catalysts in pharmaceutical nanoengineering for conveyance of helpful specialists in incessant illness diagnostics and in sensors.Herein communication we report microwave irradiation technique implemented for the preparation of novel Zinc oxide nanoparticles with beneficial bio-efficacy wherein the method employed has the advantages of producing small particle size metal oxide with high purity owing to short reaction time. We successfully synthesized and characterized two Zinc oxide based Cs₂ doped ZnO₂ and Li₂ doped ZnO₂ nanoparticles and were subjected to in vitro free radical scavenging assay wherein all the particles could scavenge DPPH and Nitric oxide radicals with less IC₅₀ value over the positive control. Microbicidal properties of nanoparticles were proved by its effectiveness against both Gram positive and Gram negative bacteria tested besides its action against Candida albicans. Both nanoparticles synthesized showed a prominent inhibition of erythrocyte lysis by PhospholipaseA2 in a concentration dependent manner indicating better anti-inflammatory agent with possibility of preventing cancer. In this study we demonstrate by shell less CAM assay that synthesized nanoparticles could inhibit in vivo angiogenesis which would otherwise under abnormal conditions causes the acceleration of several inflammatory diseases in spite of its role in normal growth and wound healing process. Inhibition of such process is the promising methodology to hinder the progression of diseases. Present characteristic features make use of ZnO₂ based doped nanoparticles to be a possible approach as a therapeutic molecule with favourable biological performance.