CYCLOHEXANE AND ITS FUNCTIONALLY SUBSTITUTED DERIVATIVES: IMPORTANT CLASS OF ORGANIC COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITIES

Abstract

Development of resistance to antimicrobial drugs is a global health concern not only for humans but also for animals. Rate of microbial resistance to antibiotics has alarmingly increased in last two decades. Factors responsible for this ever increasing antibiotic resistance are attributed to microorganisms as well as excessive and unwise use of antimicrobial drugs. Drug efflux pumps and biofilm formation are examples of microbial factors which contribute to antimicrobial resistance. It is dire need of hour to develop new antimicrobial drugs to ameliorate this condition. New antimicrobial agents with unique mode of action should be explored. In this regard, synthetic organic compounds are target of worldwide drug development studies which are being conducted for investigating new antimicrobial drugs. Cyclohexane and its functionally substituted derivatives are important compounds with diverse biological properties. These compounds can serve as probable alternatives to antibiotics with potential antimicrobial properties. This review summarizes the experimental evidences and studies exploring antimicrobial activities of cyclohexane and its functionally substituted derivatives as probable antimicrobial agents of future.