INTRACELLULAR MECHANISMS OF NATURAL SUBSTANCES INVOLVED IN THE REGULATION OF CELL SURVIVAL AND APOPTOSIS: A REVIEW

Abstract

Natural substances which are considered to be a food or part of a food that provides medical and health benefits are called nutraceuticals. Resveratrol is one of such substances that signify potential benefit as anti-carcinogenic, lowering of blood sugar level, anti-inflammatory, antioxidant and cardioprotective properties in various types of cells and animal models including inhibition of PI3K/AKT/mTOR pathway. Activation of PI3K/Akt/mTOR pathway plays a pivotal role in essential cellular functions such as survival, proliferation, migration and differentiation in various types of cells. As the in vivo functions of mTOR remain elusive is possible that mTOR plays more important roles than had been anticipated from studies.