EFFECT OF QUERCETIN AND T-2 TOXIN ON ANTIOXIDANT PARAMETERS OF PORCINE BLOOD IN VITRO

Abstract

T-2 toxin, a trichothecene mycotoxin, is considered to be a one of the most toxic compounds that is produced by molds, particularly the Fusarium species. Mycotoxins can contaminate a large variety of feed mixtures, and could cause serious health problems to domestic livestock and humans when consumed. The aim of the present study was to investigate the effect of quercetin and T-2 toxin on some antioxidants parameters (superoxide dismutase - SOD, glutathione peroxidase - GPx) in porcine blood in vitro. Application of quercetin in different doses (1, 10, 100 mg.ml-1) and T-2 toxin (1000 ng.ml-1) has caused significant decrease of SOD activity. Differences among the groups in the case of GPx activity remained insignificant (P<0.05). In this study the additions of quercetin and T-2 toxin in different doses in porcine blood in vitro caused significantly (P<0.05) lower SOD activity in all experimental groups in comparison with the control group.