THE EFFECT OF RAPAMYCIN ON SECRETORY ACTIVITY OF THE RABBIT OVARIAN FRAGMENTS
Keywords:
rapamycin, progesterone, testosterone, estradiol, prolactin, rabbit ovariesAbstract
The aim of our study was to examine the effect of rapamycin on secretory activity of the rabbit ovarian fragments. The secretion of steroid (progesterone, testosterone, estradiol) and peptide (prolactine) hormones by ovarian fragments after rapamycin addition at the doses 0, 1, 10, 100 μg.ml-1 was determined. Fragments were incubated with rapamycin for 48 hours. Hormones were determinated by RIA. The experimental data showed that, addition of rapamycin did not affect progesterone and prolactine release (at all doses). Estradiol secretion was inhibited by rapamycin at the doses of 1, 10 and 100 μg.ml-1. Testosterone was inhibited by the rapamycin at the doses of 1 and 10 μg.ml-1 but not at 100 μg.ml-1. In conclusion, our results suggest a direct effect of rapamycin on ovarian functionsand a possible involvement in the regulation of steroidogenesis.Downloads
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Published
2012-02-01
How to Cite
Kádasi*, A., V. Sirotkin, A., Maruniaková, N., Nath, S., & Kolesárová, A. (2012). THE EFFECT OF RAPAMYCIN ON SECRETORY ACTIVITY OF THE RABBIT OVARIAN FRAGMENTS. Journal of Microbiology, Biotechnology and Food Sciences, 1(4), 488–497. Retrieved from https://office2.jmbfs.org/index.php/JMBFS/article/view/7245
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Biotechnology
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Copyright (c) 2012 Attila Kádasi*, Alexander V. Sirotkin, Nora Maruniaková, Sushmita Nath, Adriana Kolesárová
This work is licensed under a Creative Commons Attribution 4.0 International License.
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