ANTIMICROBIAL ACTIVITY OF COPPER(II) COMPLEXES

Authors

  • Andrea Čongrádyová
  • Klaudia Jomová
  • Lenka Kucková
  • Jozef Kožíšek
  • Ján Moncoľ
  • Marián Valko

Keywords:

5-chlorosalicylic acid, antimicrobial activity, copper complex, 1, 10-phenanthroline, neocuproine

Abstract

Two novel copper(II) 5-chlorosalicylate complexes with either 1,10-phenantroline or its methyl derivative 2,9-dimethyl-1,10-phenanthroline (neocuproine) have been prepared and studied. A potential antimicrobial or antifungal activity of both complexes has been tested on prokaryotic Escherichia coli and eukaryotic Saccharomyces cerevisiae model organisms. Crystal structure of [Cu(phen)(5-Clsal)(5-ClsalH2)]2 a dimeric structure, whereas the second complex of formula [Cu(H2O)(5-Clsal)(Neo)] has been shown to be monomeric. Our results confirmed the toxic effect of prepared copper complexes as well as bioactive ligands on the yeast and bacteria growth. The effect of copper complexes was stronger compared to the solutions of free ligands. Our preliminary results showed that the complex [Cu(H2O)(5-Clsal)(Neo)] exhibited higher antimicrobial activity compared to the complex [Cu(phen)(5-Clsal)(5-ClsalH2)]2.

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Published

2014-02-01

How to Cite

Čongrádyová, A., Jomová, K., Kucková, L., Kožíšek, J., Moncoľ, J., & Valko, M. (2014). ANTIMICROBIAL ACTIVITY OF COPPER(II) COMPLEXES. Journal of Microbiology, Biotechnology and Food Sciences, 3(special issue 1 (Microbiology), 67–70. Retrieved from https://office2.jmbfs.org/index.php/JMBFS/article/view/7599

Issue

Vol. 3 No. special issue 1 (Microbiology) (2014): February

Section

Microbiology

License

Copyright (c) 2014 Andrea Čongrádyová, Klaudia Jomová, Lenka Kucková, Jozef Kožíšek, Ján Moncoľ, Marián Valko

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All papers published in the Journal of Microbiology, Biotechnology and Food Sciences  are published under a CC-BY licence (CC-BY 4.0). Published materials can be shared (copy and redistribute the material in any medium or format) and adapted (remix, transform, and build upon the material for any purpose, even commercially) with specifying the author(s).

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