CADMIUM AND DIAZINON-INDUCED CHANGES IN THE RAT TESTIS STRUCTURE AFTER A PERORAL ADMINISTRATION IN DRIKING WATER

Authors

  • Róbert Toman
  • Mária Adamkovičová
  • Peter Massányi
  • Michal Cabaj
  • Norbert Lukáč
  • Monika Martiniaková
  • Radoslav Omelka

Keywords:

testis, histology, morphometry, rat, cadmium, diazinon, fertility

Abstract

The present study was carried out to elucidate the effects of heavy metal cadmium (Cd) and a nonselective organophosphorus insecticide diazinon (DZN) administration on the testis structures in adult male rats in subchronic toxicity experiments. A total of 40 Wistar 4 weeks old rats were randomized into 4 groups of 10 animals each and dosed with cadmium (Cd) 30 mg/l (group A), diazinon (DZN) 40 mg/l (group B), and in combination of Cd and DZN (30 and 40 mg/l, respectively, group C) per os in drinking water for 90 days. Testicular histology using a light microscopy and morphometry using PC morphometric software M.I.S. Quick Photo were evaluated. The morphometric data supported histological observations at tubular and interstitial level. Reduced seminiferous epithelium (P<0.001) in Cd group showed desquamation of germ cells, cellular degeneration and necrosis. Increase in epithelial vacuoles and dilated blood vessels relative volume (P<0.001) were observed in all experimental groups. Cd and DZN and their combination exerted changes in the reproductive parameters which could be subsequently negatively related to male fertility. These data provide a novel insight into the reproductive toxicology of Cd-DZN in male rats. However, results did not indicate synergistic or additional effect of simultaneous administration of both toxicants.

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Published

2012-10-01

How to Cite

Toman, R., Adamkovičová, M., Massányi, P., Cabaj, M., Lukáč, N., Martiniaková, M., & Omelka, R. (2012). CADMIUM AND DIAZINON-INDUCED CHANGES IN THE RAT TESTIS STRUCTURE AFTER A PERORAL ADMINISTRATION IN DRIKING WATER. Journal of Microbiology, Biotechnology and Food Sciences, 2(2), 564–575. Retrieved from https://office2.jmbfs.org/index.php/JMBFS/article/view/7165

Issue

Section

Biotechnology

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