COMPARISON TRANSGENIC AND NON-TRANSGENIC MILK QUALITY
Keywords:
transgenic rabbit, mWAP-hFVIII, milk qualityAbstract
Transgenic founder rabbits carrying a gene construct consisting of a 2.5 kb murine whey acidic protein promoter (mWAP), 7.2 kb of the human clotting factor VIII (hFVIII) cDNA and 4.6 kb of 3’ flanking sequences of mWAP gene were crossed for five generations. Transgenic females showed high level of recombinant hFVIII (rhFVIII) mRNA expression in biopsed mammary gland tissues. The presence of the mWAP-hFVIII transgene in rabbit genome and secretion of rhFVIII into milk of transgenic females (F1, F2, F3, F4 and F5 generation) did not have any adverse phenotypic effect on milk quality.Downloads
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Published
2012-02-01
How to Cite
Chrenek, P., & Makarevich, A. (2012). COMPARISON TRANSGENIC AND NON-TRANSGENIC MILK QUALITY . Journal of Microbiology, Biotechnology and Food Sciences, 1(Special issue), 632–639. Retrieved from https://office2.jmbfs.org/index.php/JMBFS/article/view/7393
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Section
Biotechnology
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Copyright (c) 2012 Peter Chrenek, Alexander Makarevich
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