DO PUNICALAGINS HAVE POSSIBLE IMPACT ON SECRETION OF STEROID HORMONES BY PORCINE OVARIAN GRANULOSA CELLS?

Authors

  • Dagmara Packová
  • Adriana Kolesárová

DOI:

https://doi.org/10.15414/jmbfs.2016.5.special1.57-59

Keywords:

Progesterone, 17β-estradiol, granulosa cells, punicalagins, steroidogenesis

Abstract

Punicalagin is a major component responsible for pomegranate's antioxidant properties. Punicalagin is the predominant ellagitannin of Punica granatum and present in two isomeric forms; punicalagin α and β. Punicalagins are metabolised to ellagic acid (antioxidant) and microorganisms present in colon can metabolize ellagic acid to urolithins – each other substances could be responsible for effect on cell intracellular mechanism. The aim of our study was to observe the effect of punicalagins on secretion of steroids hormones – progesterone and 17β-estradiol. Ovarian granulosa cells were cultivated during 24h without (control group) and with various doses (0.01, 0.1, 1, 10 and 100 µg.ml-1) of pomegranate compounds – punicalagins. Steroid hormones progesterone and 17β-estradiol were evaluated by ELISA. Obtained results showed that the secretion of progesterone and 17β-estradiol by ovarian granulosa cells was not significantly (P≥0.05) influenced by punicalagins. In this pilot study no effects of punicalagins on porcine ovarian granulosa cells were found.

Downloads

Download data is not yet available.

Downloads

Published

2016-02-08

How to Cite

Packová, D., & Kolesárová, A. (2016). DO PUNICALAGINS HAVE POSSIBLE IMPACT ON SECRETION OF STEROID HORMONES BY PORCINE OVARIAN GRANULOSA CELLS?. Journal of Microbiology, Biotechnology and Food Sciences, 5(special 1), 57–59. https://doi.org/10.15414/jmbfs.2016.5.special1.57-59

Issue

Section

Biotechnology

Most read articles by the same author(s)

<< < 1 2 3 4 5 6 7 > >>