TOXICITY OF NANOPARTICLES ON ANIMAL AND HUMAN ORGANISM: CELL RESPONSE

Authors

  • Kateryna Vanivska Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Institute of Applied Biology, Trieda Andreja Hlinku 2, 94976 Nitra, Slovak Republic https://orcid.org/0009-0009-7886-7492
  • Lucia Dianová Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Institute of Applied Biology, Trieda Andreja Hlinku 2, 94976 Nitra, Slovak Republic https://orcid.org/0000-0003-0221-3563
  • Marko Halo Jr. Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Institute of Applied Biology, Trieda Andreja Hlinku 2, 94976 Nitra, Slovak Republic https://orcid.org/0000-0002-7059-1841
  • Nikola Štefunková Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Institute of Applied Biology, Trieda Andreja Hlinku 2, 94976 Nitra, Slovak Republic
  • Michal Lenický Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Institute of Applied Biology, Trieda Andreja Hlinku 2, 94976 Nitra, Slovak Republic
  • Tomáš Slanina Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Institute of Applied Biology, Trieda Andreja Hlinku 2, 94976 Nitra, Slovak Republic
  • Filip Tirpák University of Missouri, S141 ASRC, 920 East Campus Drive, Columbia, MO 65211-5300, USA https://orcid.org/0000-0001-9293-9055
  • Peter Ivanič Slovak Biological Services, Kremnička 2, 97405 Banská Bystrica, Slovak Republic
  • Robert Stawarz University of the National Education Commission, Krakow; Faculty of Exact and Natural Sciences, ul. Podchorążych 2, 30-084 Kraków, Poland
  • Peter Massányi Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Institute of Applied Biology, Trieda Andreja Hlinku 2, 94976 Nitra, Slovak Republic https://orcid.org/0000-0002-4216-0948

DOI:

https://doi.org/10.55251/jmbfs.10844

Keywords:

nanoparticles, toxicity, cells, in vitro, in vivo

Abstract

The review focuses on research related to the effect of nanoparticles on cells in the animal and human body and on the analysis of potential biological effects that may be caused by exposure to these materials. This review deals with the mechanisms through which nanoparticles interact with cells and analyses their potential consequences for an individual's health. The main mechanisms of toxicity are oxidative stress, inflammatory responses, cell damage, and genetic changes that can lead to apoptosis or other cellular responses. These effects are often modified by various factors, including the size and shape of the nanoparticles, their surface treatment and chemical composition. The work highlights significant differences in the responses of cells of different organ systems to nanoparticles, thereby pointing the need for a more precise examination of toxic effects depending on the biological context. This review also discusses important methods for assessing nanoparticle toxicity, including in vitro experiments, in vivo animal studies, and various clinical studies. The aim of this review was to provide a comprehensive overview of this important issue, which has significant implications for public health and the environment. Research into nanoparticles and their interaction with cells is crucial for a better understanding the risks associated with their exposure and for the development of safe technologies and applications that use these materials.

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Published

2024-05-10

How to Cite

Vanivska, K., Dianová, L., Halo Jr., M., Štefunková, N., Lenický, M., Slanina, T., Tirpák, F., Ivanič, P., Stawarz, R., & Massányi, P. (2024). TOXICITY OF NANOPARTICLES ON ANIMAL AND HUMAN ORGANISM: CELL RESPONSE. Journal of Microbiology, Biotechnology and Food Sciences, e10844. https://doi.org/10.55251/jmbfs.10844

Issue

Section

Biotechnology

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