ARE DENDRITIC CELLS A POTENTIAL TOOL FOR MASTITIS VACCINE DEVELOPMENT?

Abstract

Mastitis is one of the main disease causing big economic losses to dairy farmers. This disease is caused mainly by bacteria. Because of not efficient vaccines, there are necessary to develop new immunotherapy of vaccination strategy to reduce this disease in dairy farms. Dendritic cells are antigen-presenting cells which are able to present antigen to lymphocytes. They are able to induce activation of T naïve lymphocytes. Dendritic cells were used for development of dendritic cell-based anti-tumor vaccines. Development of vaccines against bovine mastitis has many limitations as high number of various pathogens that are able to cause inflammation of mammary gland in cattle; absence of mucus barrier in mammary gland; reduced phagocytic efficiency because of casein and fat globules etc. To this day, it is not available vaccine against bovine mastitis with high efficiency. Development of new immunotherapy or vaccine against mastitis would be very desirable. In this mini review, we are considering possibilities for development of new dendritic cell-based vaccine against bovine mastitis.